Other Services

Caenorhabditis elegans comprises unique features that make it a popular model system in diverse fields of biology. To better serve our customers, we also provide other services, including C. elegans histology service, GFP conjugation service, microinjection service, isolation and culture of C. elegans cells, strain maintenance and storage service, and services to isolate and identify C. elegans from the natural habitat. With well-established methods, advanced technology platforms and experienced experts, we promise to provide our customers with the most reliable and efficient research services to best match their research objectives.

Service offerings

C. elegans histology service

Despite a simple organism, the nematode C. elegans has defined tissues, including digestive, reproductive, and excretory systems. Previous studies have indicated that sectional histology can be applied to define novel phenotypes in C. elegans. We provide enzyme histochemistry and other staining methods combined with fresh frozen serial sections to analyze nematodes' metabolism.

C. elegans morphology visualized by H&E staining.C. elegans morphology visualized by H&E staining. (Hench J, et al. 2011)

GFP service in C. elegans

Green fluorescent protein (GFP) is first used in C. elegans. Nowadays, it has become one of the standard research tools to be used with the worm. Therefore, we provide GFP service, including GFP reporter gene constructs, germline-mediated transformation by microparticle bombardment, to meet the particular needs of our clients' research.

C. elegans microinjection service

For model organism C. elegans, microinjection is a common technique used to assemble genetic and molecular analysis to phenotypic analysis. The technique is a powerful tool that facilitates the implementation of technologies, including clustered regularly interspersed short palindromic repeats (CRISPR)-Cas9 system and RNA interference (RNAi). We offer C. elegans microinjection service to satisfy the needs of clients' research.

Microinjection scheme for C. elegans hermaphrodite- Creative BiogeneMicroinjection scheme for C. elegans hermaphrodite - Creative Biogene

Isolation and culture of C. elegans cells

Cell isolation and culture are essential tools for the study of cell function, having some advantages that can't be replaced with whole animals or even tissue explants. The isolated cells of C. elegans are also an important model system. And the cells can be used to study electrophysiology, cell autonomous development/behavior, and analysis of single-cell profiling. We have developed an efficient and technically simple platform for large-scale isolation and primary culture C. elegans cells from both embryos and all four larval stages.

C. elegans strain maintenance and storage service

We also offer C. elegans strain maintenance services to help our customers to preserve valuable C. elegans strains and keep them healthy there's an emergency. Additionally, we will package and ship the worms as soon as possible when our customers are ready to resume their experiments.

C. elegans Isolation and Identification from Natural Habitat

Research that investigating genetic and phenotypic variation based on C. elegans wild isolates has emerged. Some of the marked phenotypic differences between C. elegans natural variations have been genetically and molecularly identified through quantitative genetic mapping approaches. Therefore, the characterization of the nematode wild isolates may elucidate C. elegans biology from a novel perspective. Here, we provide the service for sampling, isolation and identification of C. elegans wild isolates.

Creative Biogene is a trusted partner. We are committed to serving our customers with high quality, reproducible results. If you are interested in our services, please contact us for more details.

Reference

  1. Hench, J., et al. (2011). "A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans." PLoS One, 6(12), e28417.

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