Customized CRISPR/Cas9 C. elegans Model Service

Basic DNA editing using CRISPR/CAS systems- Creative BiogeneBasic DNA editing using CRISPR/CAS systems Targeted changes in the genome offer the ability to address fundamentally important questions. Genome editing tools based on the CRISPR-Cas9 system are a breakthrough technology, which can precisely modify a genome in a relatively simple manner.

How it works

The system is RNA-based bacterial defense mechanisms designed to recognize and eliminate foreign DNA from invading bacteriophage and plasmids. They consist of a Cas endonuclease that is directed to cleave a target sequence by a guide RNA (gRNA). Therefore, the system can be co-opted to cleave any target sequence of choice by modifying the sequence of the gRNA, which is encoded by a "CRISPR/array" in the bacterial genome.

Available services

  • Mutation via CRISPR gene editing
    - Precise sequence/gene deletion
    - Precise point mutations
    - Precise sequence knock-in
    - Precise sequence replacement
  • Mark by CRISPR gene editing
    - Fluorescent tag
    - Immunotag
    - Custom tags and combinations are also available

Workflow of C. elegans model customization using CRISPR/Cas9

CRISPR/Cas9 system was first adapted for C. elegans in 2013, and has been successfully applied to C. elegans nowadays. We have established an efficient genome editing platform for delivering genetically engineered C. elegans optimized to meet your specifications.

Workflows of customized CRISPR/Cas9 C. elegans model service - Creative BiogeneWorkflows of customized CRISPR/Cas9 C. elegans model service - Creative Biogene

Features of our services

  • High-efficiency CRISPR technology platform.
  • Whole-process technical trace service.
  • Convenient and efficient transportation service.
  • One-stop solutions.
  • Most competitive prices.

Creative Biogene offers a series of CRISPR/Cas9 C. elegans model customization services that are part of our integrated portfolio of custom C. elegans model development services. We are committed to offering convenient and efficient transportation services with shorter turnaround time and lower prices. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us for more details.

References

  1. Au V, et al. (2019). "CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans." G3 (Bethesda). 9(1):135-144.
  2. Paix A, et al. (2017). "Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans." Methods. 121-122:86-93.

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