C. elegans has received much attention since it was introduced in the early 1970s. A number of traits facilitate genetic and genomic analysis, including the hermaphroditic lifestyle, short 2–3 weeks lifespan, and small genome, which make C. elegans an ideal compromise between complexity and tractability. The nematode now is a powerful experimental organism for the implementation of a vast array of technologies and applied in much biological research. Unlike other single-celled organisms, such as bacteria and yeast, the millimeter-long body of C. elegans contains muscles, nerves, sexual organs, and guts, and has brought a wealth of information at the cellular level. It reacts to different environments and exhibits different responses.
Aging is a complex biological process characterized by degenerative changes that progressively diminish function, leading to disease, and ultimately, death. Since it has long been a concern, the research of aging involved in gene expression and multiple pathways has been widely studied and reported. Due to the experimental challenges of studying aging in humans or other vertebrates are substantial, the easy-culturing nematode C. elegans is an excellent model system for studies of aging based on the identification of mutations, drugs, and environmental factors that extend the adult lifespan significantly. Here we offer a series of measurements of age-associated changes that serve as biomarkers indicative of the physiological status of aging to provide information for aging research, therefore, providing great convenience for our customers.
C. elegans has proven to be an exceptionally useful and efficient tool to evaluate the impact of various genetic, physiological and environmental factors on organismal aging. Creative Biogene offers a lifespan testing service for automating various facets of the collection and analysis of C. elegans lifespan experimental data using an advanced microfabricated device combining with a considerate protocol that evaluates the reliability of lifespan assay. The procedure can easily be adapted to assay lifespan under various common conditions, such as a diet consisting of live bacteria, dietary restriction, and RNA interference.
Morphological change is one of the most intuitive measurements that can be analyzed as a valuable biomarker for aging research, including body size, pharynx, bacterial content, body wall muscles, and germline. When choosing Creative Biogene, you can acquire reliable and comprehensive data of age-related indicators.
|Age-related morphology||Body size|
|Body wall muscles|
One of the important aspects to describe the age-related process is behavioral change. C. elegans possesses a number of well-defined and easily measurable behaviors that can be acquired in experiment, although the process is tedious and time-consuming. Creative Biogene offers a number of behavioral measurements and analyses of C. elegans to enable our customers to access many reliable and useful measuring values. The measurements are below.
|Age-related behavior||Pharyngeal pumping|
Like many other physiological systems, the reproductive system of C. elegans undergoes age-dependent changes, including a significant decrease in the reproduction rate, and deteriorating reproductive system structure with age. For the model system C. elegans, reproduction is a simple and effective behavior that is continuously modulated in response to environmental stimuli and easily be observed. Creative Biogene offers reproductive capacity analysis services for our customers to quickly achieve research goals.
Apart from age-related morphological change and behavioral change, biochemical change is a key aging biomarker indicative of the physiological status of aging. The age-related biochemical change contains the generation of fluorescent compounds, the level of DNA damage, the content of protein carbonylation, the amount of yolk protein in the body cavity, metabolic activity, and enzymatic activities. Creative Biogene offers a series of age-related biochemical measurements to evaluate the treatment with factors, such as mutations, drugs, diet, and environmental conditions that influence aging.
|Age-related biochemical indexes||Pharyngeal pumping|
|Lipofuscin andadvanced glycosylation end products|
|DNA damage, protein carbonylation, yolk protein in the body cavity|
Creative Biogene offers a series of thoughtful age-related measurement services, including lifespan testing, age-related morphological detection, age-related behavioral detection, reproductive capacity analysis. Our goal is to provide great convenience for our customers, by promoting the experimental progress of aging research and delivering reliable report data. If you are interested in our services or have any questions about our services, please don't hesitate to contact us for more details.
* For research use only.